We aim to provide a collection of the most clinically useful papers in Otolaryngology – Head and Neck Surgery for quick review and reference. We designate many as landmark articles (based on our criteria*), in addition to the systematic reviews, clinical trials, best practices, and other high yield research we include. This list is a great resource for residents to read relevant literature and gain knowledge on the most influential studies done in ENT. This is an ever growing list so please feel free to contact us if additional papers should make this list.
General Otolaryngology
Allergy:
Infectious:
- LANDMARK: Using antibiotics in otitis media with effusion – Review
- LANDMARK: Adenotonsillectomy for recurrent throat infection
Sleep:
- LANDMARK: Uvulopalatopharyngoplasty (UPPP) for treatment of obstructive sleep apnea
- LANDMARK: Staging of Obstructive Sleep Apnea
- LANDMARK: Sleep nasal endoscopy to assess level of obstruction in OSA
- LANDMARK: Sleep disordered breathing staging
- LANDMARK: Long-term cardiovascular outcomes in patients with OSA
- LANDMARK: Intranasal steroids for pediatric mild OSA
- LANDMARK: Evaluating the reliability of drug-induced sleep endoscopy
- LANDMARK: Assessing pediatric sleep disordered breathing
- LANDMARK: Adenotonsillectomy outcomes in pediatric OSA
- LANDMARK: Adenotonsillectomy for pediatric obstructive sleep apnea
Other:
- LANDMARK: Validity of the reflux finding score
- LANDMARK: Validating the Eustachian Tube Dysfunction Questionnaire
- LANDMARK: Role of acid and pepsin in laryngeal injury
Additional High Yield Reading:
- The sleep heart study
- Mediterranean diet vs Proton Pump Inhibitor for Reflux
- Ibuprofen and Post-tonsillectomy hemorrhage
- Guidelines on Using Perioperative Antibiotics in Otolaryngology – Head and Neck Surgery
- Consensus statement on allergic rhinitis
Head and Neck
General Principles:
- LANDMARK: Quality of life assessment for head and neck cancer patients
- LANDMARK: Unresectable recurrence of squamous cell carcinoma of the head and neck treated with reirradiation and chemotherapy (RTOG 9610) – Clinical Trial
- LANDMARK: HPV related cystic lymph node metastasis
- LANDMARK: Salvage surgery for recurrent aerodigestive tract squamous cell carcinoma
- LANDMARK: Head and neck cancer surgical margins
- LANDMARK: Stopping alcohol and tobacco use and its effect on head and neck cancer risk
Oral Cavity:
- LANDMARK: Oral cavity carcinoma tumor thickness and nodal involvement – Literature Review
- LANDMARK: Oral dysplasia treatment and follow up – Systematic Review
- LANDMARK: Prognostic pattern indicators for early oral cavity cancer
- LANDMARK: The importance of tumor thickness in oral cavity cancer
Oropharynx:
- LANDMARK: TORS for base of tongue neoplasms – Clinical Trial
- LANDMARK: Transoral laser surgery for advanced oropharyngeal cancer
- LANDMARK: p16 as a marker for HPV oropharyngeal cancer
- LANDMARK: HPV Prevalence in oropharyngeal and nonoropharyngeal cancer – Systematic Review
- LANDMARK: Transoral Robotic Surgery – Feasibility, safety and margins
- LANDMARK: HPV and Oropharngeal cancer survival
Larynx:
- LANDMARK: Laryngeal cancer and changing patterns
- LANDMARK: Narrow Band Imaging of Laryngeal Cancer
- LANDMARK: The RTOG 91-11 Trial – Treatments for advance laryngeal cancer for organ preservation
- LANDMARK: Using Lasers for laryngeal cancer
- LANDMARK: The VA Trial – Optimal treatment for advance laryngeal cancer
- LANDMARK: Patient preference for speech versus survival in laryngeal cancer
Salivary:
- LANDMARK: Prognostic factors associated with salivary gland carcinomas
- LANDMARK: A 35 year experience with salivary gland neoplasms
- LANDMARK: Complications rate after Extracapsular Dissection of Benign Parotid Lesions
Endocrine:
Cutaneous Malignancy:
Neck:
- LANDMARK: Oral cavity carcinoma tumor thickness and nodal involvement – Literature Review
- LANDMARK: Observation versus Completion Neck Dissection in Sentinel-Node Metastasis of Melanoma
- LANDMARK: PET-CT or Neck Dissection for Head and Neck Cancer
Radiation and Chemotherapy:
- LANDMARK: Nutrition in head and neck cancer patients getting radiation
- LANDMARK: Unresectable recurrence of squamous cell carcinoma of the head and neck treated with reirradiation and chemotherapy (RTOG 9610) – Clinical Trial
- LANDMARK: Risk levels of locally advanced disease using concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)
Additional High Yield Reading:
- Oral cavity cancer survival with surgery and radiation versus chemoradiation
- Oral cavity cancer local recurrence and margin distance
- Opioid use after oral cavity cancer surgery
- Papillary thyroid cancer survival and lymph node density
- Neurocognitive deficits in Head and Neck Cancer patients after radiotherapy or chemotherapy
- Survival after surgery in head and neck cancer patients and time to radiation
- Head and Neck Cancer HPV status and overall survival
- SYSTEMATIC REVIEW: Treatment delay in head and neck cancer patients and survival
- BEST PRACTICE: Genetic testing in head and neck paraganglioma
Laryngology
Benign Lesions:
Malignant Lesions:
- LANDMARK: Laryngeal cancer and changing patterns
- LANDMARK: Narrow Band Imaging of Laryngeal Cancer
- LANDMARK: Ni Classification for laryngeal cancer using narrow band imaging
- LANDMARK: Changes in Laryngeal Cancer demographics and treatment
- LANDMARK: The RTOG 91-11 Trial – Treatments for advance laryngeal cancer for organ preservation
- LANDMARK: Using Lasers for laryngeal cancer
- LANDMARK: The VA Trial – Optimal treatment for advance laryngeal cancer
- LANDMARK: Patient preference for speech versus survival in laryngeal cancer
Reflux:
- LANDMARK: Validity of the reflux finding score
- LANDMARK: Role of acid and pepsin in laryngeal injury
- LANDMARK: Validating the Reflux Symptom Index
Rhinology
Olfaction/Taste:
- LANDMARK: UPenn smell identification test
- LANDMARK: Bitter taste receptor T2R38 risk factor for sinus surgery
- LANDMARK: Olfactory retraining efficacy – Systematic Review
Inflammatory:
- LANDMARK: Survival in acute fungal sinusitis
- LANDMARK: Orbital complications of acute sinusitis
- LANDMARK: Post-operative care after endoscopic sinus surgery – Systematic Review
- LANDMARK: Smoking and chronic rhinosinusitis
- LANDMARK: Topical treatments in chronic rhinosinusitis – Systematic Review
- LANDMARK: Topic agents and distribution to sinus cavities – Systematic Review
- LANDMARK: Bitter taste receptor T2R38 risk factor for sinus surgery
- LANDMARK: SNOT-22 domains can predict treatment selection in CRS patients
- LANDMARK: Cost of chronic rhinosinusitis
- LANDMARK: Incidence of major complications in FESS
- LANDMARK: Asthma prevalence in patients with chronic rhinosinusitis
- LANDMARK: Polyp recurrence after sinus surgery in chronic rhinosinusitis patients
- LANDMARK: Microbial dysbiosis in chronic rhinosinusitis
- LANDMARK: Long-term outcomes of balloon catheter sinusotomy
- LANDMARK: Multicenter analysis of outcomes in balloon catheter sinusotomy
- LANDMARK: Sinus surgery outcomes in CRS patients with and without nasal polyps
- LANDMARK: Facial Pain with no evidence of Sinonasal disease on Examination or Imaging
- LANDMARK: Long-term outcomes in Functional Endoscopic Sinus Surgery
- LANDMARK: Smell and Taste Disorders
- LANDMARK: Validity of the Sinonasal Outcome Test Score (SNOT-20)
- LANDMARK: Major Complications of Endoscopic Sinus Surgery
- LANDMARK: Quality of life measures when looking at medical management versus surgery for chronic rhinosinusitis
- LANDMARK: Quality of Life after sinus surgery
- LANDMARK: Pediatric FESS versus Balloon catheter sinuplasty and ethmoidectomy
Malignant Neoplasm:
Skull Base:
Additional High Yield Reading:
- Consensus statement on rhinosinusitis
- RCT: Corticosteroid nasal irrigation in patients with chronic rhinosinusitis after surgery
- RCT: Budesonide nasal saline irrigations for chronic rhinosinusitis
Otology
Middle ear:
- LANDMARK: Validating the Eustachian Tube Dysfunction Questionnaire
- LANDMARK: MRI for post-operative cholesteatoma – Systemic Review
- LANDMARK: Antibiotic treatments of chronic draining ears
- LANDMARK: Children’s Hospital of Philadelphia (CHOP) Congenital Cholesteatoma Experience
Hearing/Tinnitus:
- LANDMARK: Hearing loss association with cognition and dementia
- LANDMARK: Pediatric unilateral hearing loss
- LANDMARK: Long-term stapedectomy outcomes
- LANDMARK: Oral versus Intratympanic corticosteroid treatment for SSNHL
Cochlear Implant:
- LANDMARK: Cochlear implant outcomes due to electrode location and surgical approach
- LANDMARK: Cochlear Implant for children – Review
- LANDMARK: Cochlear implants in children
Additional High Yield Reading:
- Hearing loss in children
- Tinnitus and migraines
- Hearing loss and cognition
- Hearing loss and comorbidities
Pediatric Otolaryngology
Airway:
- LANDMARK: Staging for Recurrent Respiratory Papillomatosis
- LANDMARK: Propranolol Treatment for Infant Hemangiomas
- LANDMARK: The Cotton-Myer grading system for subglottic stenosis
Hearing:
- LANDMARK: Pediatric unilateral hearing loss
- LANDMARK: Cochlear Implant for children – Review
- LANDMARK: Early vs Delayed tympanostomy tube insertion
- LANDMARK: Cochlear implants in children
- LANDMARK: Children’s Hospital of Philadelphia (CHOP) Congenital Cholesteatoma Experience
- LANDMARK: Antibiotic use for otitis media with effusion in pediatric patients
- LANDMARK: When to place tympanostomy tubes based on developmental outcomes later in childhood
Sleep Disordered Breathing:
- LANDMARK: Adenotonsillectomy outcomes in pediatric OSA
- LANDMARK: Intranasal steroids for pediatric mild OSA
- LANDMARK: Post-operative hemorrhage after tonsillectomy
- LANDMARK: Adenotonsillectomy for pediatric obstructive sleep apnea
- LANDMARK: Assessing pediatric sleep disordered breathing
Other:
- LANDMARK: Ankyloglossia treatment – Review
- LANDMARK: Using antibiotics in otitis media with effusion – Review
- LANDMARK: Adenotonsillectomy for recurrent throat infection
- LANDMARK: Pediatric FESS versus Balloon catheter sinuplasty and ethmoidectomy
Additional High Yield Reading:
Facial Plastics and Reconstruction
Aging Face:
- LANDMARK: Rhytidectomy and fascial planes
- LANDMARK: Composite platysmaplasty
- LANDMARK: Corset platysmaplasty
- LANDMARK: Deep plane rhytidectomy
- LANDMARK: SMAS anatomy in the parotid region
- LANDMARK: Frontal branch of the facial nerve and face lifts
- LANDMARK: Anatomy of blepharoplasty for herniated fat
Facial Trauma:
Reconstruction:
*These are the landmark papers in Otolaryngology – Head and Neck Surgery that are most useful for clinical practice. On OtoNotes, we determine if a paper is a Landmark Paper based on several conditions. To be considered a Landmark Paper, the article must have clinical significance and relevance. We do not include any basic science papers in this list. Papers should have more than 100 citations or an average of 50 citations per decade. We tried to limit all papers to after the year 1980 to maintain relevancy to today’s clinical practice. This is a growing list but please contact us if there are any articles you think should be on this list.