LANDMARK: Skull Base Reconstruction – Systematic Review Endoscopic skull base reconstruction of large dural defects: A Systematic Review of Published Evidence Harvey RJ, Parmar P, Sacks R, Zanation AM. Endoscopic skull base reconstruction of large dural defects: a systematic review of published evidence. Laryngoscope. 2012;122(2):452-9. Overall CSF leak rate was 11.5% (70/609). Free grafts – 15.6% leak rate (51/326) Vascularized reconstruction – 6.7% leak rate (19/283)